Parkinson's disease essay

Parkinson ' s disease - wikipedia


parkinson's disease essay

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The benefits are small and may not be noticed. Daytime sleepiness and fatigue may be treated with modafinil (Provigil) a drug used to treat narcolepsy or methylphenidate (Ritalin) may be considered for fatigue. Glycopyrrolate, scopolamine, and injections of botulinum toxin may be used to relieve drooling symptoms (Brunton, Chabner, knollman, 2011). Advanced Parkinsons disease poses challenges for the patient and caregivers. Eventually, symptoms such as stooped posture, freezing, and speech difficulties may no longer respond to drug therapy. Surgery (deep brain stimulation) may be considered. Patients become increasingly dependent on others for care and require assistance with daily tasks.

Parkinson s disease essay?

The standard preparations, sinemet and Atamet, combine levodopa with carbidopa, a drug that slows the breakdown of levodopa. Levodopa is better at improving motor problems than dopamine agonists but increases the risk of involuntary movements. Effectiveness tends to decrease after four to five years of use (Brunton, Chabner, knollman, 2011). Dopamine agonists drugs mimic dopamine to stimulate the dopamine system in the brain. The drugs included are pramipexole (Mirapex ropinirole (Requip bromocriptine (Parlodel and rotigotine (Neupro) (Katzung, mastes, trevor, giving 2012). Monoamine oxidase b inhibitors may have some mild benefits in initial therapy; they include selegiline (Eldepryl) and rasagiline (Azilect and they slow the breakdown of dopamine that occurs naturally in the brain and dopamine produced by levodopa (Katzung, mastes, trevor, 2012). Entacapone (comtan) is a catechol-o-methyl transferase (comt) inhibitor that helps to prolong the effects of levodopa by blocking an enzyme that breaks down dopamine (Brunton, Chabner, knollman, 2011). Medications to treat other symptoms associated with Parkinsons disease include antidepressants. Tricyclics, particularly Amitriptyline (Elavil studies indicate that the use of ssris may worsen symptoms. Anti-psychotics include clozapine and quetiapine help with psychotic symptoms seen with Parkinsons disease (Brunton, Chabner, knollman, 2011). The cholinesterase inhibitor drugs donepezil (Aricept) and rivastigmine (Exelon) are used to treat Alzheimers disease and are sometimes used for Parkinsons disease.

No treatment method has been proven to change the course of the disease. For early disease, with little or no impairment, drug therapy may not be necessary (Kofman). There is no cure for Parkinsons disease, but medications, physical therapy, and surgical interventions can help control symptoms and improve the quality of life (Connelly fox, 2012). The goals of treatment are to relieve disabilities and balance the problems of the disease with the side effects of the medications. A number of issues must be considered in choosing a medication warming for treatment. These include the effectiveness of the medication, the side effects of the medication, and the loss of effectiveness over time (Brunton, Chabner, knollman, 2011). Levodopa (L-dopa) has been used for years and is the gold standard for treatment. L-dopa increases brain levels of dopamine. It is probably the most effective drug for controlling symptoms and is used in all phases of the disease.

parkinson's disease essay

Essay on the Shaking Palsy

Motor impairment of the muscles in the throat impairs swallowing and poses a risk for aspiration pneumonia. Other complications of Parkinsons disease include sleep disorders, sexual dysfunction, bowel and bladder complications, and sensory problems, such as the loss of smell (Kofman). There is no cure for Parkinsons disease. Treatment mainly relies on replacing dopamine with focus on controlling symptoms and improving quality of life (Katzung, mastes, trevor, 2012). Because parkinsons disease symptoms are due to a deficiency of the brain chemical dopamine, the brain drug treatment help increase dopamine levels in the brain. Levodopa, usually in combination with carbidopa, is the standard drug treatment (Katzung, mastes, trevor, 2012). For patients who do not respond to levodopa, dopamine agonists may be prescribed. Physical therapy is an important part of Parkinsons disease treatment. Rehabilitation can help improve balance, mobility, speech and functional abilities.

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Mental manifestations may appear in the form of cognitive, perceptual, and memory deficits. A number of psychiatric manifestations (personality changes, psychosis, dementia, confusion) are writers particularly common among the elderly (Kofman). Complications from immobility (pneumonia, urinary tract infection) and the consequences of falls and accidents are major causes of death (Kofman). Early diagnosis of Parkinsons disease can be difficult, as the patient can rarely pinpoint when symptoms started. Often someone close to the patient notices a change such as stooped posture, stiff arm, a slight limp, or tremor. Handwriting changes pollution may be an early diagnostic clue.

The diagnosis of Parkinsons disease can usually be made with certainty when there is evidence of tremor, rigidity, and bradykinesia (Brunton, Chabner, knollman, 2011). The results of the patients history and neurological examination are carefully evaluated. Without treatment Parkinsons disease progresses over ten to fifteen years to a rigid, akinetic state in which patients are incapable of caring for themselves (Brunton, Chabner, knollman, 2011). The availability of effective pharmacological treatment has altered the prognosis of Parkinsons disease; in most cases, functional mobility can be maintained for many years. Life expectancy of adequately treated patients is increased substantially (Brunton, Chabner, knollman, 2011). The presence of dysphagia is associated with shorter survival times.

The clinical manifestations of Parkinsons disease are impaired movement, muscle rigidity, tremor, muscle weakness, and loss of postural reflexes. Early signs include a stiffening of the extremities and a wax-like rigidity in the performance of all movements. The patient has difficulty in initiating, maintaining, and performing motor activities, and experiences some delay in carrying out normal activity (Kofman). As the disease progresses, the tremor begins, frequently in one hand and arm, then the other, and later in the head, although the tremor may remain unilateral. The tremor is characteristic: it is a slow, turning motion (pronation-supination) of the forearm and the hand, and motion of the thumb against the fingers as if rolling a pill between the fingers.


It increases when the patient is concentrating or feels anxious (Connelly fox, 2012). Other characteristics of the disease affect the face, stature, and gait. There is loss of normal arm swing. Eventually, the rigid extremities become weaker. Since there is limited movement in the muscles, the face has so little expression that it is said to be masklike (with infrequency of blinking a feature that can be recognized at a glance (Connelly fox, 2012). There is a loss of postural reflexes, and the patient stands with head bent forward and walks as if in danger of falling forward. Difficulty in pivoting and loss of balance may lead to frequent falls (Katzung, mastes, trevor, 2012). Frequently, these patients show signs of depression, and it has not been established whether the depression is a reaction to the disorder or related to a biochemical abnormality.

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Although dopamine normally exists in high concentration in certain parts of the brain, in Parkinsons disease it is depleted in the substania nigra and the corpus striatum. Depletion of dopamine levels in the basal ganglia is associated with bradykinesia, rigidity, and tremors (Brunton, Chabner, knollman, 2011). Regional cerebral blood flow is reduced in patients with Parkinsons disease, and there is a high prevalence of dementia. Biochemical and pathologic data suggest that demented patients with Parkinsons disease may have coexistent Alzheimers disease (Connelly fox, 2012). In the majority of patients, the cause of the disease is unknown. Arteriosclerotic assignments Parkinsonism is seen more frequently in older age groups. It may follow encephalitis, poisoning, or toxicity (manganese, carbon monoxide or hypoxia, or may be drug induced. The disease most frequently attacks persons in their fifties and sixties and is the second most common neurologic disorder of the elderly (Brunton, Chabner, knollman, 2011).

parkinson's disease essay

Scientists have made great discoveries in the study of Parkinsons and they are coming close to curing this terrible disease. Treatments and studies that have been done show promising data in the process of curing or preventing this disease by focusing on the lrrk2 gene alone. If the causes of the neurodegeneration that is the onset of Parkinsons could be better understood, then maybe a specific treatment can be fabricated to slow, halt or reverse its process (Stanley fahn, 2006). Print, reference this, published: 31st January, 2018. management 31st January, 2018. Trimble, parkinsons disease, parkinsons disease is a progressive neurologic disorder affecting the brain centers that are responsible for control and regulation of movement. It is characterized by bradykinesia (slowness of movement tremor, and muscle stiffness or rigidity (Katzung, mastes, trevor, 2012). The major lesion appears to result in a loss of pigmented neurons, particularly those in the substantia nigra of the brain. The substantia nigra is a collection of midbrain nuclei that project fibers to the corpus striatum. One of the major neurotransmitters in this area of the brain, and in other parts of the central nervous system, is dopamine, which has an important inhibiting function in the central control of movement (Brunton, Chabner, knollman, 2011).

of behaviors lowers the rates and lessens the symptoms of the disease, one thing that has helped most people is exercise. One study found that young men who work out have a 60 lower risk of developing pd, and surprisingly, two things that you would never expect to help Parkinsons, first coffee is shown to reduce the risk of pd, it is thought to be because. The second thing that helps is cigarette smoking, though the costs greatly outweigh the benefits. Sergey brin, a scientist, carries the lrrk2 gene, and with daily exercise at the pool and green tea, for its caffeine content, he hopes to diminish his chance of developing pd, by adjusting his activity/caffeine algorithm and counteracting his dna with these environmental factors. Brin is a 36 year old man, but he is not just the average joe, he is half of the partnership that founded google and he is now worth 15 billion, and he has contributed 50 million to parkinsons research. He doesnt look to cure the disease, but rather to provide a method of escape from the disease in the first place. In conclusion, parkinsons disease may only directly affect about a million people in the. But it touches the lives of billions of individuals, millions of families, and thousands of scientists that all devote their lives to the disease.

Further possible gene mutations and efforts to business identify genes influencing susceptibility to the disease in general are being studied. The identification of such susceptibility genes will eventually enable us to more accurately relegate this intricate disease (Foltynie,., sawcer,., Brayne,., barker, r, 2002, the genetic basis of Parkinsons disease). There are multiple social issues when it comes to dealing with Parkinsons, like when people dont understand or realize the full effect of Parkinsons. Shelley schwarz (2006) states that, at any age it can be difficult to share your feelings with your friends, and especially difficult if you were diagnosed at a young age like your early 20s. You may have to tell the people you see often, like your hair dresser, dentist, co-workers, or teachers about your disease so that they know you might shake, move slowly, fall, lose balance, or have trouble speaking. There are even racial stereotypes involved with Parkinsons, mentioned in an article in the sun Sentinel (Brochu, 2013) The michael. Fox foundation for Parkinsons Research is testing for possible clues to preventing and curing the disease, the study hopes to test about four hundred Ashkenazi jews for the llrk2 gene which is the most common link connected to parkinsons to date (Brochu). The llrk2 gene, which is located on the 12th chromosome, is a genetic mutation that has been seen in most of the people that have been diagnosed with Parkinsons.

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Parkinsons disease (PD) is a progressive, lingering, and usually fatal movement disorder. Progressive meaning the symptoms are always present and worsen over time. This disease is wide spread and there are nearly one million people in the. This disease does not have a known cure yet, but you can treat and manage the symptoms with medication and surgery. Parkinsons disease involves the malfunction and death of vital cells in the brain, called neurons, and affects the area of the brain called the substania nigra (Parkinsons Disease foundation, 2014, Understanding Parkinsons). The specific symptoms that are normally associated with Parkinsons include tremors of the hands, arms, legs, jaw, and face, slowness of movement, stiffness of the limbs and joints, frequent imbalance and lack of coordination(pdf, 2014, Understanding Parkinsons). Scientists are exploring the hypothesis that cell loss and death in other areas of the brain and body could contribute to the development or worsening of Parkinsons. The processes of neurodegeneration and the theories behind the development of Parkinsons have been resume studied for years but are still not fully understood (Foltynie,., sawcer,., Brayne,., barker, r, 2002 there is considerable evidence that suggests that multiple factors, including genetic background, amount. In a few families, parkinsons disease is known to be inherited in a mendelian fashion (Foltynie,., sawcer,., Brayne,., barker, r and in some of these cases, the genes that cause this disease have already been recognized and the possible pathogenic instruments that.


Parkinson's disease essay
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Free essay: Parkinson s disease is an incurable neurological disorder that aff ects 3 of the elderly population. Classified as a movement disorder,.

5 Comment

  1. Read all about Parkinson s Disease including the causes, sympt oms. In his Essay parkinson described the characteristic resting tremor. Parkinson s disease is a chronic, progressive, movement disorder that affects muscle control and balance. These symptoms gradually worsen over time, and.

  2. It primarily impacts the specific. Parkinson s disease is a progressive neurologic disorder affec ting the brain centers that are responsible for control and regulation. This free health essay on Essay: Parkinson s disease (PD) is perfect for healt h students to use as an example.

  3. The publication titled An Essay on the Shaking Palsy help established. Parkinson s disease as an accepted medical condition. Free essay: Introduction Parkinson disease (PD) is a progressive neurodegenerative disorder characterized mainly by physical and psychological disabilities. Parkinson s disease is a degenerative neurological disease that affects approx imately one million persons in the United States.

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